Publications
Scientific Publications
2024
- Freeze, Robert, Philip Hughes, Timothy Haystead, and Scott Scarneo. "Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Alleviates Inflammatory Joint Pain in Osteoarthritis and Gouty Arthritis Preclinical Models." Journal of Pain Research (2024): 2287-2298.
- Damhofer, Helene, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom et al. "TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers." Cell Death & Disease 15, no. 4 (2024): 273.
2023
- Freeze, Robert, Kelly W. Yang, Timothy Haystead, Philip Hughes, and Scott Scarneo. "Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis." Pharmacology Research & Perspectives 11, no. 4 (2023): e01124.
- Scarneo, Scott, Xin Zhang, Yaomin Wang, Jose Camacho-Domenech, Jennifer Ricano, Philip Hughes, Tim Haystead, and Andrea G. Nackley. "Transforming growth factor-β-activated kinase 1 (TAK1) mediates chronic pain and cytokine production in mouse models of inflammatory, neuropathic, and primary pain." The journal of pain 24, no. 9 (2023): 1633-1644.
- Bale, Swarna, Priyanka Verma, Bharath Yalavarthi, Scott Arthur Scarneo, Philip Hughes, M. Asif Amin, Pei-Suen Tsou et al. "Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis." JCI insight 8, no. 14 (2023).
2022
2020
- Scarneo, S. A., Hughes, P. F., Yang, K. W., Carlson, D. A., Gurbani, D., Westover, K. D., & Haystead, T. A. (2020). A highly selective inhibitor of interleukin-1 receptor–associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. Journal of Biological Chemistry, 295(6), 1565-1574.
- Totzke, J., Scarneo, S. A., Yang, K. W., & Haystead, T. A. (2020). TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases. Open Biology, 10(9), 200099.
- Scarneo, S. A., Yang, K. W., Roques, J. R., Dai, A., Eibschutz, L. S., Hughes, P., & Haystead, T. A. (2020). TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades. Oncotarget, 11(21), 1961.